Journal of Medicinal Chemistry
Volume 42, Issue 16 (August 12, 1999)
Copyright © 1999 American Chemical Society

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COMMUNICATIONS

3011-3013

A Novel Acetylated Analogue of Dynorphin A-(1-11) Amide as a -Opioid Receptor Antagonist Qiang Wan, Thomas F. Murray, and Jane V. Aldrich [Full Article - PDF]

3014-3017

Synthesis and Enantiomeric Separation of 2-Phthalimidino-glutaric Acid Analogues: Potent Inhibitors of Tumor Metastasis Jamshed H. Shah, Glenn M. Swartz, Adonia E. Papathanassiu, Anthony M. Treston, William E. Fogler, John W. Madsen, and Shawn J. Green [Full Article - PDF]

3018-3022

Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities David Bom, Dennis P. Curran, Ashok J. Chavan, Stefan Kruszewski, Stephen G. Zimmer, Kimberly A. Fraley, and Thomas G. Burke [Full Article - PDF]

3023-3025

Discovery of 1,6-Naphthyridines as a Novel Class of Potent and Selective Human Cytomegalovirus Inhibitors Laval Chan, Haolun Jin, Tomislav Stefanac, Jean-François Lavallée, Guy Falardeau, Wei Wang, Jean Bédard, Suzanne May, and Leonard Yuen [Full Article - PDF]

3026-3032

Discovery and Synthesis of (S)-3-[2-(3,4-Dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic Acid (LU 302872), a Novel Orally Active Mixed ETA/ETB Receptor Antagonist Willi Amberg, Stefan Hergenröder, Heinz Hillen, Rolf Jansen, Georg Kettschau, Andreas Kling, Dagmar Klinge, Manfred Raschack, Hartmut Riechers, and Liliane Unger [Full Article - PDF]

3033-3040

N-Methylated Cyclic RGD Peptides as Highly Active and Selective V3 Integrin Antagonists Michael A. Dechantsreiter, Eckart Planker, Barbara Mathä, Elisabeth Lohof, Günter Hölzemann, Alfred Jonczyk, Simon L. Goodman, and Horst Kessler [Full Article - PDF]

3041-3054

Synthesis, Evaluation, and Comparative Molecular Field Analysis of 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as Ligands for Histamine H1 Receptors Ehren C. Bucholtz, Randal L. Brown, Alexander Tropsha, Raymond G. Booth, and Steven D. Wyrick [Full Article - PDF]

3055-3065

Chiral Resolution and Stereospecificity of 6-Phenyl-4-phenylethynyl- 1,4-dihydropyridines as Selective A3 Adenosine Receptor Antagonists Ji-long Jiang, An-Hu Li, Soo-Yeon Jang, Louis Chang, Neli Melman, Stefano Moro, Xiao-duo Ji, Emil B. Lobkovsky, Jon C. Clardy, and Kenneth A. Jacobson [Full Article - PDF]

3066-3074

Molecular Recognition in Nicotinic Acetylcholine Receptors: The Importance of PI-Cation Interactions Jeffrey D. Schmitt, Christopher G. V. Sharples, and W. S. Caldwell [Full Article - PDF]

3075-3086

Ochratoxin Binding to Phenylalanyl-tRNA Synthetase: Computational Approach to the Mechanism of Ochratoxicosis and Its Antagonism Daniel R. McMasters and Angelo Vedani [Full Article - PDF]

3087-3093

Lipophilic 4-Isoxazolyl-1,4-dihydropyridines: Synthesis and Structure-Activity Relationships Nicholas R. Natale, Mark E. Rogers, Richard Staples, David J. Triggle, and Aleta Rutledge [Full Article - PDF]

3094-3100

Novel Prodrug Approach for Tertiary Amines: Synthesis and Preliminary Evaluation of N-Phosphonooxymethyl Prodrugs Jeffrey P. Krise, Jan Zygmunt, Gunda I. Georg, and Valentino J. Stella [Full Article - PDF]

3101-3108

Synthesis and Characterization of Fluorescent Ligands for the Norepinephrine Transporter: Potential Neuroblastoma Imaging Agents Dirk Hadrich, Frank Berthold, Eberhard Steckhan, and Heinz Bönisch [Full Article - PDF]

3109-3115

Potent Bivalent Thrombin Inhibitors: Replacement of the Scissile Peptide Bond at P1-P1' with Arginyl Ketomethylene Isosteres Torsten Steinmetzer, Bing Yan Zhu, and Yasuo Konishi [Full Article - PDF]

3116-3125

Novel Hypotensive Agents from Verbesina caracasana. 6. Synthesis and Pharmacology of Caracasandiamide Marco Carmignani, Anna R. Volpe, Franco Delle Monache, Bruno Botta, Romulo Espinal, Stella C. De Bonnevaux, Carlo De Luca, Maurizio Botta, Federico Corelli, Andrea Tafi, Giuseppe Ripanti, and Giuliano Delle Monache [Full Article - PDF]

3126-3133

Carboxylic Acid Analogues of Tamoxifen: (Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Estrogen Receptor Affinity and Estrogen Antagonist Effects in MCF-7 Cells Kelly S. Kraft, Peter C. Ruenitz, and Michael G. Bartlett [Full Article - PDF]

3134-3146

Novel Calcium Antagonists with Both Calcium Overload Inhibition and Antioxidant Activity. 2. Structure-Activity Relationships of Thiazolidinone Derivatives Tatsuya Kato, Tomokazu Ozaki, Kazuhiko Tamura, Yoshiyuki Suzuki, Michitaka Akima, and Nobuhiro Ohi [Full Article - PDF]

3147-3153

N-Nitroarginine-Containing Dipeptide Amides. Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase Hui Huang, Pavel Martasek, Linda J. Roman, Bettie Sue Siler Masters, and Richard B. Silverman [Full Article - PDF]

3154-3162

Development of Predictive Retention-Activity Relationship Models of Tricyclic Antidepressants by Micellar Liquid Chromatography C. Quiñones-Torrelo, S. Sagrado, R. M. Villanueva-Camañas, and M. J. Medina-Hernández [Full Article - PDF]

3163-3166

New Type of Febrifugine Analogues, Bearing a Quinolizidine Moiety, Show Potent Antimalarial Activity against Plasmodium Malaria Parasite Yoshiaki Takaya, Hidehisa Tasaka, Tomoyuki Chiba, Koji Uwai, Masa-aki Tanitsu, Hye-Sook Kim, Yusuke Wataya, Masatomo Miura, Mitsuhiro Takeshita, and Yoshiteru Oshima [Full Article - PDF]

3167-3174

Cytotoxicity of 2,2':6',2' '-Terpyridineplatinum(II) Complexes against Human Ovarian Carcinoma Gordon Lowe, Anne Sophie Droz, Tirayut Vilaivan, George W. Weaver, Jenny J. Park, Jonathan M. Pratt, Lindsay Tweedale, and Lloyd R. Kelland [Full Article - PDF]

3175-3182

Constrained Corticotropin Releasing Factor Antagonists (Astressin Analogues) with Long Duration of Action in the Rat Jean E. Rivier, Dean A. Kirby, Sabine L. Lahrichi, Anne Corrigan, Wylie W. Vale, and Catherine L. Rivier [Full Article - PDF]

3183-3187

Robust QSAR Models Using Bayesian Regularized Neural Networks Frank R. Burden , David A. Winkler [Full Article - PDF]

3188-3192

Synthesis and Biological Activity of the Superestrogen (E)-17-Oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: X-ray Crystal Structure of (E)-17-Oximino-3-hydroxy-1,3,5(10)-estratriene Hatem A. M. Hejaz, Atul Purohit, Mary F. Mahon, Michael J. Reed, and Barry V. L. Potter [Full Article - PDF]